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茶堿

分析標(biāo)準(zhǔn)品,HPLC≥98%

Theophylline

CAS號(hào)：58-55-9

分子式：C7H8N4O2

分子量：180.16

MDL：MFCD00079619

別名：1,3-二甲基黃嘌呤;2,6-二氧-1,3-二甲基嘌呤;3,7-二氫-1,3-二甲基-1H-嘌呤-2,6-二酮;2,6-二羥基-1,3-二甲基嘌呤

產(chǎn)品介紹

 Theophylline (1,3-Dimethylxanthine) 是有效的磷酸二酯酶 (PDE) 抑制劑，腺苷受體拮抗劑，和組蛋白脫乙酰酶 (HDAC) 活化劑。Theophylline (1,3-Dimethylxanthine) 抑制 PDE3 活性，放松氣道平滑肌。Theophylline (1,3-Dimethylxanthine) 通過增加 IL-10 和抑制 NF-κ B進(jìn)入細(xì)胞核而具有抗炎活性。Theophylline (1,3-Dimethylxanthine) 誘發(fā)細(xì)胞凋亡 (apoptosis)。Theophylline (1,3-Dimethylxanthine) 可用于哮喘和慢性阻塞性肺疾病 (COPD) 的研究。

熔點(diǎn)：271-273℃

沸點(diǎn)：454.1℃ at 760 mmHg

外觀：白色至灰白色結(jié)晶粉末

溶解性：DMSO  :  11.11  mg/mL  (61.67  mM;  Need  ultrasonic)
H2O  :  5  mg/mL  (27.75  mM;  Need  ultrasonic)。

敏感性：對(duì)空氣敏感

儲(chǔ)存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(31篇)

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13. [IF=3.981] Lin Wang et al."Drug-drug cocrystals of theophylline with quercetin."J Drug Deliv Sci Tec. 2022 Apr;70:103228

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2.  李承浩,王萌,任曉亮.磺化杯6芳烴對(duì)4類中藥單體成分增溶作用及其機(jī)制研究[J].中國(guó)現(xiàn)代中藥,2020,22(12):2032-2038.

1.  董燕茹,曹妍彥,盧佳純,梅思凡,河潤(rùn),陳萍.兒茶素與咖啡堿絡(luò)合物的晶體學(xué)研究[J].茶葉科學(xué),2021,41(01):80-89.

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