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桔梗皂苷D

分析標(biāo)準(zhǔn)品,HPLC≥98%

Platycodin D

CAS號：58479-68-8

分子式：C57H92O28

分子量：1225.34

MDL：MFCD09952590

產(chǎn)品介紹

熔點：228-237℃

外觀：白色結(jié)晶性粉末

溶解性：難溶于水，易溶于甲醇、乙醇等有機溶劑和稀堿中。

敏感性：易吸潮

儲存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(27篇)

27. [IF=4.9] Lu Jiani et al."Exploring anti-SARS-CoV-2 natural products: dual-viral target inhibition by delphinidin and the anti-coronaviral efficacy of deapio platycodin D."Natural Products and Bioprospecting.2025 Dec;15(1):1-22

26. [IF=5.4] Yuxia Wang et al."Improvement Effect of Shengxian Decoction on Cardiac Toxicity Induced by Arsenic Trioxide in Rats."JOURNAL OF ETHNOPHARMACOLOGY.2025 Jun;:120163

25. [IF=3.2] Zhiying Feng et al."Exploration of the Active Components and Mechanism of Jiegeng (Platycodonis Radix) in the Treatment of Influenza Virus Pneumonia Through Network Pharmacology Analysis and Experimental Verification."Chemical Biology & Drug Design.2024 N

24. [IF=1.6] Shuncheng Zhao et al."Effects of electron beam irradiation on microbial load, physicochemical properties, sensory quality, stability of active components, and antioxidant activity of Platycodon grandiflorum (Jacq.) A. DC.."APPLIED RADIATION AND ISOTOPES.2

23. [IF=5.5] Liu Hui et al."Platycodin D facilitates antiviral immunity through inhibiting cytokine storm via targeting K63-linked TRAF6 ubiquitination."JOURNAL OF LEUKOCYTE BIOLOGY".2024 Mar;:

22. [IF=4.4] Pang Tao et al."Evaluating the Compatibility Mechanism of Shengxian Decoction Based on an Excretion Study of 18 Bioactive Constituents in Rat Biosamples."World Journal of Traditional Chinese Medicine".2024 Feb;10(1):40

21. [IF=4.3] Yu Hanwen et al."Identification and functional characterization of two trans-isopentenyl diphosphate synthases and one squalene synthase involved in triterpenoid biosynthesis in Platycodon grandiflorus."PLANTA.2023 Dec;258(6):1-13

20. [IF=1.8] Yan Liu et al."Effect of Developmental Stages on the Biosynthesis of Triterpene Saponins  and Related Gene Expression in  Seedlings of Platycodon grandiflorus."Natural Product Communications.10.1177/1934578X231191886

19. [IF=1.496] Xinying Du et al."Platycodin D-Induced Immunotoxicity in RAW 264.7 Macrophages via Oxidative Stress-Mediated Apoptosis."Natural Product Communications.

18. [IF=3.111] Zhen Ni et al."Platycodin D inhibits the proliferation, invasion and migration of endometrial cancer cells by blocking the PI3K/Akt signaling pathway via ADRA2A upregulation."Oncology Letters.2023 Apr;25(4):1-9

17. [IF=6.819] Chunjing  Guo et al."A novel saponin liposomes based on the couplet medicines of Platycodon grandiflorum–Glycyrrhiza uralensis for targeting lung cancer."DRUG DELIVERY

16. [IF=7.666] Shuyu Zheng et al."Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non–Small-Cell Lung Cancer."Cells.2022 Jan;11(15):2360

15. [IF=2.311] Xiaoyu Zhang et al."Effects of Platycodin D on apoptosis, migration, invasion and cell cycle arrest of gallbladder cancer cells."Oncol Lett. 2020 Dec;20(6):1-1

14. [IF=3.205] Chi Zhang et al."Components study on antitussive effect and holistic mechanism of Platycodonis Radix based on spectrum-effect relationship and metabonomics analysis."J Chromatogr B. 2021 May;1173:122680

13. [IF=3.935] Tong Xie et al."A post processing strategy to score and rank the annotation confidence of saponins in natural products by integrating MS2 spectral similarity and fragment interpretation."J Pharmaceut Biomed. 2021 Sep;204:114291

12. [IF=4.821] Xiangwei Chang et al."Untargeted metabolomics approach reveals the tissue-specific markers of balloon flower root (Platycodi Radix) using UPLC-Q-TOF/MS."Microchem J. 2021 Sep;168:106447

11. [IF=4.932] Ruiqi Guo et al."Anti-inflammatory effects of Platycodin D on dextran sulfate sodium (DSS) induced colitis and E. coli Lipopolysaccharide (LPS) induced inflammation."Int Immunopharmacol. 2021 May;94:107474

10. [IF=3.565] Ruolin Zhao et al."Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways."J Cancer. 2015; 6(7): 623–631

9.  Zhang, Chi, et al. "Components study on antitussive effect and holistic mechanism of Platycodonis Radix based on spectrum-effect relationship and metabonomics analysis." Journal of Chromatography B 1173 (2021): 122680.https:##doi.org/10.1016/j.jchromb.2021

8.  馬琳琳,何慧,張世科,李威.桔梗皂苷-D誘導(dǎo)Hela細(xì)胞凋亡的作用及機制研究[J].現(xiàn)代中西醫(yī)結(jié)合雜志,2020,29(22):2429-2436.

7.  王菊,李龍,曾家順.桔梗皂苷D對MH7A細(xì)胞遷移和侵襲的影響及其機制的研究[J].貴州醫(yī)藥,2020,44(10):1515-1517+1681.

6.  王菊,李龍,曾家順.桔梗皂苷D對MH7A細(xì)胞增殖和凋亡的影響及機制[J].貴州醫(yī)科大學(xué)學(xué)報,2020,45(10):1149-1155.

5.  曾靜凱 郭青.不同產(chǎn)地桔梗性狀、浸出物、桔梗皂苷D含量及HPLC指紋圖譜比較[J].中國實驗方劑學(xué)雜志 2017 23(24):62-70.

4.  馬琳琳, 何慧, 張世科,等. 桔梗皂苷-D誘導(dǎo)Hela細(xì)胞凋亡的作用及機制研究[J]. 現(xiàn)代中西醫(yī)結(jié)合雜志 2020年29卷22期, 2429-2436頁, ISTIC CA, 2020.

3.  趙若琳,周坤福,張旭,陳美娟.桔梗皂苷-D抑制非小細(xì)胞肺癌H460和A549細(xì)胞黏附、侵襲和遷移的作用機制研究[J].中國藥理學(xué)通報,2015,31(02):241-247.

2.  朱立芬, 王冰. 桔梗皂苷D防御口腔黏膜上皮細(xì)胞感染白色念珠菌的作用[J]. 中國病理生理雜志, 2017(1):161-165.

1.  文宇萍, 金鐵. 機筒溫度與物料含水量對擠壓桔梗的膨化特性及桔梗皂苷D含量的影響[J]. 延邊大學(xué)農(nóng)學(xué)學(xué)報, 2019, 041(003):83-88.