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和厚樸酚

分析標(biāo)準(zhǔn)品,HPLC≥98%

Honokiol

CAS號：35354-74-6

分子式：C18H18O2

分子量：266.33

MDL：MFCD00016674

產(chǎn)品介紹

熔點：87.5℃

沸點：400.1℃ at 760 mmHg

外觀：棕褐色至白色精細(xì)粉末，單體為無色鱗片狀晶體

溶解性：可溶于一般的有機(jī)溶劑，易溶于苯，乙mi，氯仿，乙醇等，難溶于水。

儲存條件：2-8℃

注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

參考文獻(xiàn)(39篇)

39. [IF=8.2] Yaxiong Chen et al."Honokiol protects against heavy-ion radiation-induced oxidative damage via the thioredoxin system."FREE RADICAL BIOLOGY AND MEDICINE.2025 Jun;:

38. [IF=1.7] Yu-Han Piao et al."Integrating Intestinal Biotransformation and Gut Microbiota to Uncover the Influence of Tongfu Xiexia Decoction in Rats With Constipation."RAPID COMMUNICATIONS IN MASS SPECTROMETRY.2025 May;39(15):e10065

37. [IF=4.8] Feng-lin Zhang et al."Huashi baidu granule alleviates inflammation and lung edema by suppressing the NLRP3/caspase-1/GSDMD-N pathway and promoting fluid clearance in a porcine reproductive and respiratory syndrome (PRRS) model."JOURNAL OF ETHNOPHARMACOLOG

36. [IF=3.8] Xu Wang et al."A HPLC-assisted mathematical prediction method of ternary solvent systems to develop an intelligent online selection system for countercurrent chromatography solvent system."JOURNAL OF CHROMATOGRAPHY A.2024 Dec;:465585

35. [IF=6.8] Lin Lin et al."Rhynchophylline as an agonist of sirtuin 3 ameliorates endothelial dysfunction via antagonizing mitochondrial damage of endothelial progenitor cells."BRITISH JOURNAL OF PHARMACOLOGY.2025 Mar;:

34. [IF=4.8] Haitao Li et al."Honokiol relieves hippocampal neuronal damage in Alzheimer's disease by activating the SIRT3‐mediated mitochondrial autophagy."CNS Neuroscience & Therapeutics.2024 Aug; 30(8): e14878

33. [IF=8.2] Yulong Wei et al."New insight into molecular mechanisms of different polyphenols affecting Sirtuin 3 deacetylation activity."INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES".2024 May;:132026

32. [IF=3] Xiaoshuang He et al."Affinity character analysis of magnolol and honokiol based on stepwise frontal analysis coupled with cell membrane chromatography."JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES.2023 Sep;1229:12

31. [IF=5.4] Zhaoyi Ye et al."Zhi-Zi-Hou-Po decoction alleviates depressive-like behavior and promotes hippocampal neurogenesis in chronic unpredictable mild stress induced mice via activating the BDNF/TrkB/CREB pathway."JOURNAL OF ETHNOPHARMACOLOGY.2024 Jan;319:117355

30. [IF=4.5] Guangtao Pan et al."Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways."Journal of Traditional and Complementary Medicine.10.1016/j.jtcme.2023.09.001

29. [IF=2.866] Sun, Guang-wei et al."Honokiol Reduces Mitochondrial Dysfunction and Inhibits Apoptosis of Nerve Cells in Rats with Traumatic Brain Injury by Activating the Mitochondrial Unfolded Protein Response."JOURNAL OF MOLECULAR NEUROSCIENCE.2022 Dec;:1-9

28. [IF=3.251] Kanglei Zhang et al."Honokiol Antagonizes Cadmium-Induced Nephrotoxicity in Quail by Alleviating Autophagy Dysfunction, Apoptosis and Mitochondrial UPR Inhibition with Its Antioxidant Properties."Life-Basel.2022 Oct;12(10):1574

27. [IF=11.467] Xinmian Chen et al."Local delivery of gambogic acid to improve anti-tumor immunity against oral squamous cell carcinoma."JOURNAL OF CONTROLLED RELEASE.2022 Nov;351:381

26. [IF=4.927] Wenguang Jing et al."Application of Multiple-Source Data Fusion for the Discrimination of Two Botanical Origins of Magnolia Officinalis Cortex Based on E-Nose Measurements, E-Tongue Measurements, and Chemical Analysis."MOLECULES.2022 Jan;27(12):3892

25. [IF=3.373] Kewei Zhang et al."Discrimination between raw and ginger juice processed Magnoliae officinalis cortex based on HPLC and Heracles NEO ultra-fast gas phase electronic nose."Phytochemical Analysis. 2022 Mar 22

24. [IF=1.719] Xiaoying Zhu et al."Honokiol suppresses TNF-α-induced migration and matrix metalloproteinase expression by blocking NF-κB activation via the ERK signaling pathway in rat aortic smooth muscle cells."Acta Histochem. 2014 May;116:588

23. [IF=1.902] Junjun Wang et al."The pharmacokinetics and tissue distribution of curcumin and its metabolites in mice."Biomed Chromatogr. 2018 Sep;32(9):e4267

22. [IF=2.939] Fan  Shuli et al."Honokiol Inhibits Tumor Necrosis Factor-α-Stimulated Rat Aortic Smooth Muscle Cell Proliferation via Caspase- and Mitochondrial-Dependent Apoptosis."Inflammation. 2014 Feb;37(1):17-26

21. [IF=3.205] Dong-Dong Hu et al."Simultaneous determination of ten compounds in rat plasma by UPLC-MS/MS: Application in the pharmacokinetic study of Ma-Zi-Ren-Wan."J Chromatogr B. 2015 Sep;1000:136

20. [IF=5.418] Qiu  Ling et al."Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IκB/NF-κB, in atherosclerotic cell model."Exp Mol Med. 2015 Jul;47(7):e171-e171

19. [IF=5.81] Zhang  Xianhua et al."Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats."Front Pharmacol. 2018 Mar;0:131

18.  Qiu, Ling, et al. "Honokiol ameliorates endothelial dysfunction through suppression of PTX3 expression, a key mediator of IKK/IκB/NF-κB, in atherosclerotic cell model." Experimental & molecular medicine 47.7 (2015): e171-e171.

17.  Zhang X, Han L, Liu J, et al. Pharmacokinetic Study of 7 Compounds Following Oral Administration of Fructus Aurantii to Depressive Rats. Frontiers in Pharmacology. 2018 ;9:131. DOI: 10.3389/fphar.2018.00131. PMID: 29556193; PMCID: PMC5845165.

16.   Li, J. , et al. "A novel quality evaluation method for magnolia bark using electronic nose and colorimeter data with multiple statistical algorithms - ScienceDirect." Journal of Traditional Chinese Medical Sciences 7. 2(2020):221-227.DOI： 10.1016/j.jtcms.

15.  莉莉,陳勇,張蒙偉,鄢紅霞,高守紅,陳萬生.UHPLC-MS/MS法測定新冠肺炎經(jīng)驗方寒濕郁肺湯中11種主成分的含量[J].藥學(xué)實踐雜志,2021,39(02):148-151+156.

14.  焦韻蘋,張珩,李思維,宋宵.和厚樸酚對鼻咽癌細(xì)胞增殖、遷移和侵襲的分子機(jī)制研究[J].臨床醫(yī)學(xué)研究與實踐,2020,5(28):5-8.

13.  荊文光, 張權(quán), 鄧哲,等. 指紋圖譜、多成分定量與化學(xué)計量學(xué)相結(jié)合的厚樸藥材質(zhì)量評價[J]. 中國中藥雜志, 2019, 44(5).

12.  劉娜, 袁金鳳, 謝登香,等. 基于多成分定量比較厚樸姜制前后化學(xué)成分的變化[J]. 中南藥學(xué), 2020, v.18;No.173(06):118-122.

11.  張權(quán), 荊文光, 程顯隆,等. 基于9種成分測定的厚樸炮制過程質(zhì)量傳遞規(guī)律研究[J]. 中草藥, 2020, v.51;No.662(03):96-101.

10.  黃彧, 吳桐, 劉春明,等. 探針?biāo)幬锓ㄔu價厚樸酚、和厚樸酚對大鼠肝微粒體中CYP450酶的抑制作用[J]. 中國現(xiàn)代應(yīng)用藥學(xué), 2019, 36(04):392-396.

9.  黃彧, 劉春明, 吳桐,等. 超高效液相色譜-高分辨質(zhì)譜分析大鼠肝微粒體中厚樸酚與和厚樸酚的體外代謝[J]. 分析科學(xué)學(xué)報, 2019, 035(002):145-151.

8.  張權(quán), 荊文光, 鄧哲,等. 基于相對質(zhì)量常數(shù)的姜厚樸飲片等級評價[J]. 中國實驗方劑學(xué)雜志, 2019, v.25(22):122-127.

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5.  楊巖  肖佳妹  易子漾 等. 厚樸超臨界CO_2提取工藝優(yōu)化及提取物抗氧化活性研究[J]. 中草藥  2020.

4.  李陽  羅菊元  陳功森 等. 北京市零售藥店姜厚樸飲片質(zhì)量分析[J]. 現(xiàn)代中藥研究與實踐  2018  032(002):58-61.

3.  荊文光  張權(quán)  杜杰 等. 不同產(chǎn)地厚樸藥材中3種木脂素類成分含量測定及聚類分析[J]. 世界科學(xué)技術(shù):中醫(yī)藥現(xiàn)代化  2018  020(010):1822-1827.

2.  朱林峰  ZHU Linfeng  張媛 等. "發(fā)汗"對厚樸藥材質(zhì)量影響的研究及其工藝的建立[J]. 中國現(xiàn)代中藥  2019  21(11):1551-1556.

1.  唐蘭如 陳一楨 張文娟 王俏 劉紅 陳勇.Box-Behnken Design-響應(yīng)面優(yōu)化法優(yōu)化PEG化和厚樸酚長循環(huán)納米脂質(zhì)體處方[J].湖北大學(xué)學(xué)報(自然科學(xué)版) 2018 40(04):418-423.

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